Black phosphorus nanoparticles for dual therapy of non-small cell lung cancer.

Abstract

Lung cancer remains one of the leading causes of death in humans. Gefitinib is an inhibitor of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) commonly used to suppress tumour growth. However, constantly use of gefitinib results in drug-resistance, reduced efficacy and undesired side effects. To circumvent these drawbacks, targeted and photothermal therapies have emerged as effective strategies. Herein, we are first to adopt a black phosphorus (BP) nanoparticle-based novel delivering strategy by combining gefitinib and cancer cytomembrane to treat non-small cell lung cancer (NSCLC). In these gefitinib-containing nano-carriers, cyanine 5 (Cy5) biotin-labelled BP was incorporated with cancer membrane and then consists of a nanomaterial (BPGM), which enabled to deliver gefitinib to the tumours effectively. The combination of BPGM showed reinforcing effects to suppress NSCLC cells and xenograft tumours without apparent adverse effects both in vitro and in vivo. BPGM facilitated the delivery of gefitinib to tumour tissue and extended its retention time within tumours. These studies thus suggest that BP may serve as novel delivery strategy for lung cancer.

• Authors: Zhongxiao Lin, Qiudi Deng, Qi Fang, Xinzhi Li, Xiaoyan Liu, Jianglin Wang, Sheng Chen, Xiaotao Huang, Langyu Yang, Yingling Miao, Xi-Yong Yu
• Journal: Journal of drug targeting (J Drug Target) Vol. 30 Issue 6 Pg. 614-622 (07 2022) ISSN: 1029-2330 [Electronic] England
• PMID: 35078385 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Protein Kinase Inhibitors
• Quinazolines
• Phosphorus
• ErbB Receptors
• Gefitinib

Topics

• Antineoplastic Agents (adverse effects)
• Carcinoma, Non-Small-Cell Lung (drug therapy, pathology)
• Cell Line, Tumor
• Drug Resistance, Neoplasm
• ErbB Receptors (genetics)
• Gefitinib (pharmacology, therapeutic use)
• Humans
• Lung Neoplasms (drug therapy, pathology)
• Mutation
• Nanoparticles
• Phosphorus (pharmacology, therapeutic use)
• Protein Kinase Inhibitors (pharmacology)
• Quinazolines (therapeutic use)