Marine Depsipeptide Nobilamide I Inhibits Cancer Cell Motility and Tumorigenicity via Suppressing Epithelial-Mesenchymal Transition and MMP2/9 Expression.

Abstract

A cyclic depsipeptide, nobilamide I (1), along with the known peptide A-3302-B/TL-119 (2), was isolated from the saline cultivation of the marine-derived bacterium Saccharomonospora sp., strain CNQ-490. The planar structure of 1 was elucidated by interpretation of 1D and 2D NMR and MS spectroscopic data. The absolute configurations of the amino acids in 1 were assigned by using the C3 Marfey's analysis and comparing them with those of 2 based on their biosynthetic pathways. Nobilamide I (1) decreased cell motility by inhibiting epithelial-mesenchymal transition markers in A549 (lung cancer), AGS (gastric cancer), and Caco2 (colorectal cancer) cell lines. In addition, 1 modulated the expression of the matrix metalloproteinase (MMP) family (MMP2 and MMP9) in the three cell lines.

• Authors: Tu Cam Le, Sultan Pulat, Jihye Lee, Geum Jin Kim, Haerin Kim, Eun-Young Lee, Prima F Hillman, Hyukjae Choi, Inho Yang, Dong-Chan Oh, Hangun Kim, Sang-Jip Nam, William Fenical
• Journal: ACS omega (ACS Omega) Vol. 7 Issue 2 Pg. 1722-1732 (Jan 18 2022) ISSN: 2470-1343 [Electronic] United States
• PMID: 35071867 (Publication Type: Journal Article)
• Copyright: © 2022 The Authors. Published by American Chemical Society.