Usefulness of Living Donor Liver Transplantation for Patients After Undergoing the Kasai Operation for Biliary Atresia.

Abstract

BACKGROUND:

Living donor liver transplantation (LDLT) has been actively performed for patients with poor clearance of jaundice after the Kasai operation for biliary atresia (BA). The present study clarified the usefulness of LDLT for BA.

MATERIALS AND METHODS:

Between 2000 and 2020, 24 patients (late group) underwent radical surgery for BA in our institute. The overall survival rate, native liver survival rate, and proportion of LDLT in the late group were retrospectively compared with those of 47 patients treated before 1999 (early group). P values <.05 was considered statistically significant.

RESULTS:

The overall survival rates at 5, 10, and 15 years were 57%, 54%, and 49%, respectively, in the early group and 100%, 100%, and 100% in the late group (P < .001). The native liver survival rates at 5, 10, and 15 years were 57%, 52%, and 39%, respectively, in the early group and 57%, 49%, and 42% (P = .993) in the late group. In the early group, LDLT was performed in 7 of 47 patients (15%), and the overall survival rate after LDLT was 71%. In the late group, LDLT was performed in 11 of 24 patients (46%), and the overall survival rate after LDLT was 100%.

CONCLUSIONS:

The long-term outcomes after the Kasai operation for BA have improved in recent years. There were no marked differences in long-term native liver survival before and after 2000. LDLT was actively introduced for patients with poor clearance of jaundice after the Kasai operation, and the survival rate significantly improved.

• Authors: Takashi Kobayashi, Yoshiaki Kinoshita, Yoshiaki Takahashi, Toshiyuki Ohyama, Yuhki Arai, Naoki Yokota, Koichi Saito, Kohei Miura, Hirosuke Ishikawa, Jun Sakata, Toshifumi Wakai
• Journal: Transplantation proceedings (Transplant Proc) Vol. 54 Issue 2 Pg. 435-437 (Mar 2022) ISSN: 1873-2623 [Electronic] United States
• PMID: 35065828 (Publication Type: Journal Article)
• Copyright: Copyright © 2022 Elsevier Inc. All rights reserved.

Topics

• Biliary Atresia (surgery)
• Humans
• Infant
• Liver Transplantation (adverse effects)
• Living Donors
• Portoenterostomy, Hepatic (adverse effects)
• Retrospective Studies
• Treatment Outcome