[A Long-Survival Case of Lower Rectal Cancer with Unresectable Liver Metastases Treated with FOLFOXIRI plus Bevacizumab(BEV)].

Abstract

A woman in her 30s visited our hospital complaining primarily of melena. Colonoscopy revealed the presence of a type 1 tumor in 2 cm from anal verge. Contrast-enhanced CT showed an unresectable massive liver metastasis in the left lobe of the liver and another metastasis in the right lobe. The patient received front-line chemotherapy with Leucovorin, fluorouracil, oxaliplatin, and irinotecan(FOLFOXIRI)plus bevacizumab(BEV). A year later, a marked reduction of liver metastases and primary lesions was confirmed by CT scan imaging. A multidisciplinary team recommended resection of the liver metastases followed by laparoscopic intersphincteric resection for primary lesions. However, after 1 year, a recurrence was diagnosed in the liver; hence, FOLFOXIRI plus BEV was reintroduced for volume reduction. The patient underwent a repeat hepatectomy since enough volume reduction was confirmed. One year later, she experienced a re-relapse of the metastasis in the liver. Currently, she is still undergoing chemotherapy following 7 years since the first visit. Long-term survival can be expected following surgical treatment during chemotherapy.

• Authors: Yoshinori Kagawa, Akira Inoue, Yujiro Nishizawa, Kenji Kawai, Takashi Ohta, Taishi Hata, Atsushi Naito, Hisateru Komatsu, Yasuhiro Miyazaki, Akira Tomokuni, Masaaki Motoori, Kazumasa Fujitani, Takeshi Kato, Yutaka Takeda, Kohei Murata
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 48 Issue 13 Pg. 1819-1821 (Dec 2021) ISSN: 0385-0684 [Print] Japan
• PMID: 35046341 (Publication Type: Case Reports, Journal Article)

Chemical References

• Organoplatinum Compounds
• Bevacizumab
• Leucovorin
• Fluorouracil
• Camptothecin

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Bevacizumab (therapeutic use)
• Camptothecin (analogs & derivatives, therapeutic use)
• Colorectal Neoplasms (drug therapy)
• Female
• Fluorouracil (therapeutic use)
• Humans
• Leucovorin (therapeutic use)
• Liver Neoplasms (drug therapy)
• Neoplasm Recurrence, Local
• Organoplatinum Compounds
• Rectal Neoplasms (drug therapy, surgery)