[Changes in Renal Function and Feasibility of Adjuvant Chemotherapy for Colorectal Cancer Patients with Diverting Ileostomy after Ileal Pouch-Anal Anastomosis].

Abstract

We investigated changes in estimated glomerular filtration rate(eGFR)in 11 colorectal cancer patients(6 familial adenomatous polyposis, 5 ulcerative colitis)who underwent restorative proctocolectomy with ileal pouch-anal anastomosis(IPAA) and diverting ileostomy(DI), the tolerability and adverse events of adjuvant chemotherapy(ACT)in 4 cases. After IPAA, eGFR decreased significantly(p=0.02)and did not return to the preoperative level even after stoma closure(p<0.01). mFOLFOX6 was selected as the regimen in 4 candidates, and no significant changes in eGFR after ACT were observed. The relative dose intensity of oxaliplatin was 91.7%, and no gastrointestinal adverse events of Grade 3 or higher were observed. Although in a small number of cases, mFOLFOX6 as ACT after IPAA and DI may be feasible.

• Authors: Kenichi Chikatani, Taku Sato, Tetsuya Ito, Noriyasu Chika, Yoshitaka Toyomasu, Yoshiko Mori, Okihide Suzuki, Satoshi Hatano, Toru Ishiguro, Takatoshi Matsuyama, Yoichi Kumagai, Keiichiro Ishibashi, Erito Mochiki, Hideyuki Ishida, Hiroyuki Oya
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 48 Issue 13 Pg. 1925-1927 (Dec 2021) ISSN: 0385-0684 [Print] Japan
• PMID: 35045449 (Publication Type: Journal Article)

Topics

• Adenomatous Polyposis Coli (surgery)
• Anastomosis, Surgical
• Chemotherapy, Adjuvant
• Colitis, Ulcerative (drug therapy, surgery)
• Colonic Pouches
• Feasibility Studies
• Humans
• Ileostomy
• Kidney (physiology)
• Postoperative Complications
• Proctocolectomy, Restorative