The effect of botulinum toxin A in unilateral cleft lip scar: comparison of results with different sites of injection.
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| Abstract |
Botulinum toxin type A (BTA) injections into the subjacent orbicularis oris muscle have been shown to improve appearance and produce narrower cheiloplasty scars. This study was performed to determine the effect of BTA injected at different sites on the unilateral cleft lip scar and cleft side nostril width. A double-blind, randomized prospective trial was conducted involving 64 consecutive patients with unilateral cleft lip undergoing primary cheiloplasty between September 2016 and January 2019. The patients were randomized to receive BTA injections either into the subjacent orbicularis oris muscle (4 points group) or into the bilateral nasolabial fold region (6 points group) during cheiloplasty. The scars were assessed by photographic scar width measurements and Vancouver scar scale assessment tool. The cleft side nostril width was compared to the non-cleft side width. Fifty-six patients completed the trial, 24 in the 4 points group and 31 in the 6 points group. There was no significant difference in scar width or nostril width measurements between the groups at the end of follow-up. The Vancouver scar scale assessment was also similar between the groups. There was no significant difference in scar width or nostril width measurements after cleft lip repair between patients treated with botulinum toxin injections to the subjacent orbicularis oris muscle and patients treated with injections in the nasolabial region.
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| Authors | T-C Lu, K Bhandari, C-F Yao, P K-T Chen |
| Journal | International journal of oral and maxillofacial surgery (Int J Oral Maxillofac Surg) Vol. 51 Issue 7 Pg. 900-905 (Jul 2022) ISSN: 1399-0020 [Electronic] Denmark |
| PMID | 35012827 (Publication Type: Journal Article, Randomized Controlled Trial) |
| Copyright | Copyright © 2021 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. |
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