Paeonol administration alleviates cognitive deficits and attenuates neural pathological changes in APP/PS1 mice.

Abstract

Alzheimer's disease typically presents with impaired cognition and pathological morphologic changes, including the accumulation of amyloid-β plaques. Disease-modifying drugs are in urgent need as neuroprotective therapies. Exploration of novel therapeutics for alleviating symptoms of Alzheimer's disease has found promise in plant extracts of functional phenols. Paeonol is a water-soluble phenolic substance that has been shown to confer diverse biological effects, including neuroprotection. An Alzheimer's disease model of APP/PS1 double transgenic mice was used in this study, and the therapeutic effects of paeonol were assessed after three weeks' administration. It was found that paeonol treatment significantly increased behavioral performance in the Morris water maze test and increased discrimination rate in the novel object recognition test compared to vehicle-treated APP/PS1 mice. Histologically, paeonol treatment significantly alleviated the Aβ plaque burden, reduced neural loss, inhibited microglia activation, and decreased neuroinflammation in the brain of APP/PS1 mice. In addition, a number of Alzheimer's disease-related synaptic plasticity deficits were ameliorated. The present results indicate that paeonol significantly relieved amyloid-β deposition and amyloid-β -mediated neuropathology in the brain of APP/PS1 mice, suggesting the potential of paeonol as a preventive and therapeutic agent for Alzheimer's disease.

• Authors: Shengxi Meng, Bing Wang, Wentao Li
• Journal: Journal of integrative neuroscience (J Integr Neurosci) Vol. 20 Issue 4 Pg. 1001-1010 (Dec 30 2021) ISSN: 0219-6352 [Print] Singapore
• PMID: 34997723 (Publication Type: Journal Article)
• Copyright: © 2021 The Author(s). Published by IMR Press.

Chemical References

• Acetophenones
• Neuroprotective Agents
• paeonol

Topics

• Acetophenones (administration & dosage, pharmacology)
• Alzheimer Disease (drug therapy)
• Animals
• Behavior, Animal (drug effects)
• Cognitive Dysfunction (drug therapy)
• Disease Models, Animal
• Hippocampus (drug effects)
• Maze Learning (drug effects)
• Mice
• Mice, Transgenic
• Neuroprotective Agents (administration & dosage, pharmacology)
• Recognition, Psychology (drug effects)