Reirradiation for Nasal Cavity or Paranasal Sinus Tumor-A Multi-Institutional Study.

Abstract

We evaluated the efficacy and toxicity of reirradiation of nasal cavity or paranasal sinus tumors. We collected and analyzed multi-institutional data of reirradiation cases. Seventy-eight patients with nasal or paranasal sinus tumors underwent reirradiation. The median survival time was 20 months with a medial follow-up of 10.7 months. The 2-year local control and overall survival rates were 43% and 44%, respectively. Tumor volume (≤25 cm3), duration between previous radiotherapy and reirradiation (≤12 months), histology (squamous cell carcinoma), male sex, and lymph node involvement were predisposing factors for poor survival. Distant metastasis was observed in 20 patients (25.6%). Grade ≥ 3 adverse events were observed in 22% of the patients, including five grade 4 (8.6%) cases and one grade 5 (1.2%) case. Tumor location adjacent to the optic pathway was a significant predisposing factor for grade ≥3 visual toxicity. Reirradiation of nasal and paranasal sinus tumors is feasible and effective. However, adverse events, including disease-related toxicities, were significant. Prognostic factors emerge from this study to guide multidisciplinary approaches and clinical trial designs.

• Authors: Hideya Yamazaki, Gen Suzuki, Norihiro Aibe, Makoto Yasuda, Hiroya Shiomi, Ryoong-Jin Oh, Ken Yoshida, Satoaki Nakamura, Koji Konishi, Mikio Ogita
• Journal: Cancers (Cancers (Basel)) Vol. 13 Issue 24 (Dec 16 2021) ISSN: 2072-6694 [Print] Switzerland
• PMID: 34944935 (Publication Type: Journal Article)