Therapy-related myeloid neoplasms resembling juvenile myelomonocytic leukemia: a case series and review of the literature.

Abstract

Therapy-related myeloid neoplasms (t-MN) are a distinct subgroup of myeloid malignancies with a poor prognosis that include cases of therapy-related myelodysplastic syndrome (t-MDS), therapy-related myeloproliferative neoplasms (t-MPN) and therapy-related acute myeloid leukemia (t-AML). Here, we report a series of patients with clinical features consistent with juvenile myelomonocytic leukemia (JMML), an overlap syndrome of MDS and myeloproliferative neoplasms that developed after treatment for another malignancy.

• Authors: Astrid Wintering, Stephen Smith, Beng Fuh, Arun Rangaswami, Gary Dahl, May Chien, Tanja A Gruber, Jinjun Dang, Loretta S Li, Alicia Lenzen, Stephanie Savelli, Christopher C Dvorak, Anurag K Agrawal, Elliot Stieglitz
• Journal: Pediatric blood & cancer (Pediatr Blood Cancer) Vol. 69 Issue 5 Pg. e29499 (05 2022) ISSN: 1545-5017 [Electronic] United States
• PMID: 34939322 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
• Copyright: © 2021 Wiley Periodicals LLC.

Topics

• Humans
• Leukemia, Myelomonocytic, Juvenile (diagnosis, therapy)
• Myelodysplastic Syndromes (chemically induced, diagnosis, therapy)
• Myeloproliferative Disorders
• Neoplasms, Second Primary (diagnosis)