Tumor hypoxia substantially lowers the treatment efficacy of
oxygen-relevant therapeutic modalities because the production of
reactive oxygen species in
oxygen-relevant anticancer modalities is highly dependent on
oxygen level in
tumor tissues. Here a distinctive magnetothermodynamic anticancer strategy is developed that takes the advantage of
oxygen-irrelevant
free radicals produced from magnetothermal decomposable initiators for inducing
cancer-cell apoptosis in vitro and
tumor suppression in vivo.
Free-radical nanogenerator is constructed through in situ engineering of a mesoporous
silica coating on the surface of superparamagnetic Mn and Co-doped nanoparticles (MnFe2 O4 @CoFe2 O4 , denoted as Mag) toward multifunctionality, where mesoporous structure provides reservoirs for efficient loading of initiators and the Mag core serves as in situ heat source under alternating magnetic field (AMF) actuation. Upon exposure to an exogenous AMF, the magnetic
hyperthermia effect of superparamagnetic core lead to the rapid decomposition of the loaded/delivered initiators (AIPH) to produce
oxygen-irrelevant
free radicals. Both the magnetothermal effect and generation of toxic
free radicals under AMF actuation are synergistically effective in promoting
cancer-cell death and
tumor suppression in the hypoxic tumor microenvironment. The prominent therapeutic efficacy of this radical nanogenerator represents an intriguing paradigm of
oxygen-irrelevant nanoplatform for AMF-initiated synergistic
cancer treatment.