Abstract | BACKGROUND: The nutritional status can potentially affect the efficacy of cancer therapy. The Geriatric Nutritional Risk Index (GNRI), a simple index for evaluating nutritional status calculated from body weight and serum albumin levels, has been reported to be associated with the prognosis of various diseases. However, the relationships between GNRI and the efficacy of platinum-based chemotherapy in patients with non-small-cell lung cancer (NSCLC) are unknown. METHODS: The pretreatment levels of GNRI were retrospectively evaluated in 148 chemo-naïve patients with advanced NSCLC who received first-line platinum-based chemotherapy and scored as low or high. RESULTS: Patients with a high GNRI had a significantly higher overall response rate (ORR; 44.5% [95% confidence interval {CI} = 35.6%-53.9%] vs. 15.8% [95% CI = 7.4%-30.4%, p = 0.002), longer median progression-free survival (PFS; 6.3 months [95% CI = 5.6-7.2 months] vs. 3.8 months [95% CI = 2.5-4.7 months], p < 0.001), and longer median overall survival (OS; 22.8 months [95% CI = 16.7-27.2 months] vs. 8.5 months [95% CI = 5.4-16.0 months], p < 0.001) than those with low GNRI. High GNRI was independently predictive of better ORR in multivariate logistic regression analysis and longer PFS and OS in multivariate Cox proportional hazard analyses. In 71 patients who received second-line non- platinum chemotherapy, patients with high GNRI exhibited significantly longer PFS and OS than those with low GNRI (both p < 0.001). CONCLUSIONS:
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Authors | Masato Karayama, Yusuke Inoue, Hideki Yasui, Hironao Hozumi, Yuzo Suzuki, Kazuki Furuhashi, Tomoyuki Fujisawa, Noriyuki Enomoto, Yutaro Nakamura, Naoki Inui, Takafumi Suda |
Journal | BMC pulmonary medicine
(BMC Pulm Med)
Vol. 21
Issue 1
Pg. 409
(Dec 11 2021)
ISSN: 1471-2466 [Electronic] England |
PMID | 34895201
(Publication Type: Journal Article)
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Copyright | © 2021. The Author(s). |
Chemical References |
- Albumins
- Antineoplastic Agents
- Platinum
- Cisplatin
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Albumins
(analysis)
- Antineoplastic Agents
(therapeutic use)
- Carcinoma, Non-Small-Cell Lung
(blood, drug therapy, epidemiology)
- Cisplatin
(therapeutic use)
- Female
- Geriatric Assessment
(methods, statistics & numerical data)
- Humans
- Japan
(epidemiology)
- Lung Neoplasms
(blood, drug therapy, epidemiology)
- Male
- Middle Aged
- Nutrition Assessment
- Platinum
(therapeutic use)
- Retrospective Studies
- Risk Factors
- Survival Rate
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