Hyperthermia Effect of Nanoclusters Governed by Interparticle Crystalline Structures.

Abstract

Magnetic nanoparticles have an important role as heat generators in magnetic fluid hyperthermia, a type of next-generation cancer treatment. Despite various trials to improve the heat generation capability of magnetic nanoparticles, iron oxide nanoparticles are the only approved heat generators for clinical applications, which require a large injection dose due to their low hyperthermia efficiency. In this study, iron oxide nanoclusters (NCs) with a highly enhanced hyperthermia effect and adjustable size were synthesized through a facile and simple solvothermal method. Among the samples, the NCs with a size of 25 nm showed the highest hyperthermia efficiency. Differently sized NCs exhibit inconsistent interparticle crystalline alignments, which affect their magnetic properties (e.g., coercivity and saturation magnetization). As a result, the optimal NCs exhibited a significantly enhanced heat generation efficiency compared with that of isolated iron oxide nanoparticles (ca. 7 nm), and their hyperthermia effect on skin cancer cells was confirmed.

• Authors: Miseon Jeong, Sanghoon Lee, Dae Young Song, Sunghwi Kang, Tae-Hyun Shin, Jin-Sil Choi
• Journal: ACS omega (ACS Omega) Vol. 6 Issue 46 Pg. 31161-31167 (Nov 23 2021) ISSN: 2470-1343 [Electronic] United States
• PMID: 34841158 (Publication Type: Journal Article)
• Copyright: © 2021 The Authors. Published by American Chemical Society.