NR4A3: A Key Nuclear Receptor in Vascular Biology, Cardiovascular Remodeling, and Beyond.

Abstract

The mechanisms committed in the activation and response of vascular and inflammatory immune cells play a major role in tissue remodeling in cardiovascular diseases (CVDs) such as atherosclerosis, pulmonary arterial hypertension, and abdominal aortic aneurysm. Cardiovascular remodeling entails interrelated cellular processes (proliferation, survival/apoptosis, inflammation, extracellular matrix (ECM) synthesis/degradation, redox homeostasis, etc.) coordinately regulated by a reduced number of transcription factors. Nuclear receptors of the subfamily 4 group A (NR4A) have recently emerged as key master genes in multiple cellular processes and vital functions of different organs, and have been involved in a variety of high-incidence human pathologies including atherosclerosis and other CVDs. This paper reviews the major findings involving NR4A3 (Neuron-derived Orphan Receptor 1, NOR-1) in the cardiovascular remodeling operating in these diseases.

• Authors: José Martínez-González, Laia Cañes, Judith Alonso, Carme Ballester-Servera, Antonio Rodríguez-Sinovas, Irene Corrales, Cristina Rodríguez
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 22 Issue 21 (Oct 21 2021) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 34768801 (Publication Type: Journal Article, Review)

Chemical References

• DNA-Binding Proteins
• NR4A3 protein, human
• Nerve Tissue Proteins
• Nr4a3 protein, mouse
• Receptors, Steroid
• Receptors, Thyroid Hormone

Topics

• Animals
• Atherosclerosis
• Atrial Remodeling
• Cardiovascular Diseases (etiology, metabolism, pathology)
• Cardiovascular System (metabolism, pathology)
• DNA-Binding Proteins (metabolism, physiology)
• Humans
• Inflammation
• Nerve Tissue Proteins (metabolism, physiology)
• Pulmonary Arterial Hypertension
• Receptors, Steroid (metabolism, physiology)
• Receptors, Thyroid Hormone (metabolism, physiology)