Group VIII Metal Carbonyl Cluster-Boronic Acid Conjugates: Cytotoxicity and Mode of Action Studies.

Abstract

A set of metal carbonyl cluster-boronic acid conjugates of the group VIII metals (Fe, Ru, and Os) were synthesized and their antiproliferative effects measured against two breast cancer cell lines (MCF-7 and MDA-MB-231) and a noncancerous breast epithelial (MCF-10A) cell line. The cytotoxicity followed the order Ru > Os > Fe for the MDA-MB-231 cells, although the latter two exhibited similar cytotoxicity against MCF-7 and MCF-10A cells. The osmium species {Os3(CO)10(μ-H)[μ-SC6H4-p-B(OH)2]} (2) could be chemically oxidized to its hydroxy analogue [Os3(CO)10(μ-H)(μ-SC6H4 -p-OH)] (2-OH), which showed comparable cytotoxicity. Mode of action studies pointed to an apoptotic pathway for cell death.

• Authors: Jia Wen Kong, Zhiyong Lam, Kiat Hwa Chan, Rakesh Ganguly, Jia-Ying Joey Lee, Lit-Hsin Loo, Richard D Webster, Zhen Xuan Wong, Weng Kee Leong
• Journal: ACS omega (ACS Omega) Vol. 6 Issue 43 Pg. 29045-29053 (Nov 02 2021) ISSN: 2470-1343 [Electronic] United States
• PMID: 34746593 (Publication Type: Journal Article)
• Copyright: © 2021 The Authors. Published by American Chemical Society.