MANF: A Novel Endoplasmic Reticulum Stress Response Protein-The Role in Neurological and Metabolic Disorders.

Abstract

The mesencephalic astrocyte-derived neurotrophic factor (MANF), also named as arginine-rich protein (ARP) or arginine-rich mutated in early-stage tumors (ARMET), is a novel evolutionary conserved protein related to unfolded protein response. Growing evidence suggests that MANF critically involves in many ER stress-related diseases with a protective effect. Here, we review the function of MANF based on its structure in neurological and metabolic disorders and summarize its potential applications in disease diagnosis and therapies.

• Authors: Yang Yu, Dan-Yang Liu, Xue-Shen Chen, Ling Zhu, Li-Hong Wan
• Journal: Oxidative medicine and cellular longevity (Oxid Med Cell Longev) Vol. 2021 Pg. 6467679 ( 2021) ISSN: 1942-0994 [Electronic] United States
• PMID: 34745419 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2021 Yang Yu et al.

Chemical References

• MANF protein, human
• Nerve Growth Factors

Topics

• Endoplasmic Reticulum Stress
• Humans
• Metabolic Diseases (metabolism, pathology, therapy)
• Nerve Growth Factors (metabolism)
• Nervous System Diseases (metabolism, pathology, therapy)
• Unfolded Protein Response