Clinical Efficacy of Tacrolimus Ointment + 3% Boric Acid Lotion Joint Chinese Angelica Decoction in Chronic Perianal Eczema.

Abstract

OBJECTIVE:

To unearth the clinical efficacy of tacrolimus ointment + 3% boric acid lotion joint Chinese angelica decoction in chronic perianal eczema.

METHODS:

Patients with chronic perianal eczema admitted to hospital from June 2018 and June 2019 were retrospectively analyzed. Patients in the control group (n = 38) underwent basic therapy with tacrolimus ointment + 3% boric acid lotion, whereas those in the observation group (n = 38) were given oral Chinese angelica decoction on the basis of the above therapy. Patient's baseline information before therapy and clinical symptoms after therapy were observed and compared, including pruritus ani score, anus drainage and damp score, skin lesion score, skin lesion area score, life quality index score, and IL-2, IL-4, and IgE levels in serum. Overall efficacy in the two groups was also evaluated.

RESULTS:

No significant differences were found in the baseline information between the observation group and control group before therapy. After therapy, pruritus ani score (P = 0.023), anus drainage and damp score (P = 0.041), skin lesion score (P = 0.025), and skin lesion area score (P = 0.035) of patients in the observation group were remarkably lower than those in the control group. Significantly higher release levels of clinical symptoms of patients in the observation group were indicated. With respect to the control group, the life quality score (P = 0.020) and IgE level in serum (P = 0.003) of patients in the observation group were significantly lower, while IL-4 level in serum was significantly higher (P = 0.129). The therapy in the observation group achieved better clinical efficacy. Overall efficacy in the observation group was markedly favorable with respect to the control group.

CONCLUSION:

With respect to tacrolimus ointment + 3% boric acid lotion, patients with chronic perianal eczema displayed better clinical efficacy after jointly being treated by Chinese angelica decoction.

• Authors: Weiwei Gao, Xueli Qiao, Jinxin Zhu, Xin Jin, Yuegang Wei
• Journal: Computational and mathematical methods in medicine (Comput Math Methods Med) Vol. 2021 Pg. 1016108 ( 2021) ISSN: 1748-6718 [Electronic] United States
• PMID: 34721653 (Publication Type: Journal Article, Observational Study)
• Copyright: Copyright © 2021 Weiwei Gao et al.

Chemical References

• Boric Acids
• Drugs, Chinese Herbal
• Immunosuppressive Agents
• Ointments
• boric acid
• Tacrolimus

Topics

• Adult
• Angelica (chemistry)
• Animals
• Anus Diseases (drug therapy)
• Boric Acids (administration & dosage)
• Case-Control Studies
• Chronic Disease
• Computational Biology
• Drug Therapy, Combination
• Drugs, Chinese Herbal (administration & dosage)
• Eczema (drug therapy)
• Female
• Humans
• Immunosuppressive Agents (administration & dosage)
• Male
• Middle Aged
• Ointments (administration & dosage)
• Phytotherapy
• Pruritus Ani (drug therapy)
• Retrospective Studies
• Skin Cream (administration & dosage)
• Tacrolimus (administration & dosage)
• Treatment Outcome