131I-Labeled gold nanoframeworks for radiotherapy-combined second near-infrared photothermal therapy of cancer.

Abstract

Photothermal therapy (PTT) has shown great promise for cancer treatment via light-triggered heat generation, while the anticancer efficacy of sole PTT is often limited. In this study, we report the use of radionuclide 131I-labeled gold nanoframeworks (131I-AuNFs) for radiotherapy-combined second near-infrared (NIR-II) PTT of breast cancer. AuNFs synthesized via a simple reduction approach are surface functionalized with polydopamine and poly(ethylene glycol), followed by labeling with 131I. The formed 131I-AuNFs with a high photothermal conversion efficacy and stable radioactivity can effectively accumulate into subcutaneous 4T1 mouse models as confirmed by in vivo single photon emission computed tomography (SPECT) imaging. Upon 1064 nm laser irradiation of tumors, local heat is generated for NIR-II PTT, which combines with radiotherapy to achieve a much higher therapeutic efficacy relative to sole treatment. As such, 131I-AuNFs-mediated radiotherapy-combined NIR-II PTT results in the effective inhibition of the growth of subcutaneous tumors. This study thus provides a facile nanoplatform for effective combination cancer therapy.

• Authors: Danling Cheng, Jiali Gong, Peng Wang, Jingyi Zhu, Ningyue Yu, Jinhua Zhao, Qin Zhang, Jingchao Li
• Journal: Journal of materials chemistry. B (J Mater Chem B) Vol. 9 Issue 45 Pg. 9316-9323 (11 24 2021) ISSN: 2050-7518 [Electronic] England
• PMID: 34719700 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Iodine Radioisotopes
• Iodine-131
• Gold

Topics

• Animals
• Cell Line, Tumor
• Cell Survival
• Female
• Gold
• Iodine Radioisotopes (chemistry)
• Mammary Neoplasms, Animal (therapy)
• Metal Nanoparticles (chemistry)
• Mice
• Mice, Nude
• Photothermal Therapy (methods)
• Radiotherapy
• Random Allocation
• Xenograft Model Antitumor Assays