Efficacy and safety of Resveratrol combined with Ablative Fractional CO2 laser system in the treatment of skin photoaging.

Abstract

OBJECTIVE:

To evaluate the efficacy and safety of resveratrol combined with ablative fractional CO2  laser system (AFL) treating skin photoaging.

METHODS:

Thirty-two subjects were assigned to the treatment group (TG) or the control group (CG), respectively, applied test product (resveratrol essence) or control product twice daily for 6 months. Each subject was given an AFL treatment or no laser treatment on left or right side of the face randomly. Subjective evaluations by investigators and subjects themselves were conducted after treatment. Melanin index, erythema index, and cuticle moisture content were conducted at baseline and after treatments. Adverse events (AEs) were evaluated during the study period.

RESULTS:

All subjects in TG achieved improvements of their photoaging signs compared to pre-treatment both the laser side and the non-laser side at 6 months (p < 0.05). On the laser side, TG produced a better improvement than CG at 6 months (p < 0.05). On the laser side, the difference values of MI in TG at the 2 months after enrollment (M2), M3, and M4 were more obvious than those in CG (p < 0.05). On the non-laser side, the difference values of MI in TG at M3, M4, M5, and M6 were more obvious than those of CG (p < 0.05). Subjects in TG were more likely to have tingling and had a faster subsidence of erythema mild edema, and pigmentation induced by AFL compared to CG.

CONCLUSION:

The resveratrol can improve photoaging alone and add an efficacy to the AFL treatment and subside the AEs induced by AFL.

• Authors: Yi-Mei Du, Jing Zeng, Meng Li, Yang-Bin Wang, Yan Wu, Rui-Qun Qi, Xing-Hua Gao, Hong-Duo Chen
• Journal: Journal of cosmetic dermatology (J Cosmet Dermatol) Vol. 20 Issue 12 Pg. 3880-3888 (Dec 2021) ISSN: 1473-2165 [Electronic] England
• PMID: 34719113 (Publication Type: Journal Article)
• Copyright: © 2021 Wiley Periodicals LLC.

Chemical References

• Carbon Dioxide
• Resveratrol

Topics

• Carbon Dioxide
• Erythema (etiology)
• Humans
• Lasers, Gas (adverse effects)
• Resveratrol (therapeutic use)
• Skin Aging
• Treatment Outcome