Abstract | BACKGROUND: PATIENTS AND METHODS: This study included 481 patients who underwent curative treatment for gastric cancer between 2013 and 2017. The risk factors for overall (OS) and recurrence-free (RFS) survival were identified. RESULTS: A CAR of 0.05 was regarded as the optimal critical point of classification considering the 3- and 5-year survival rates and patients were divided according to their CAR. The OS rates at 3 and 5 years after surgery were significantly higher at 92.5% and 87.9%, respectively, in the low-CAR group compared with 84.9% and 71.9%, respectively, in the high-CAR group. The corresponding RFS rates were 89.1% and 85.5%, and 81.0% and 72.2%, respectively, also a significant difference. A multivariate analysis demonstrated that the CAR was a significant independent risk factor for the OS and marginally significant independent risk factor for the RFS. In addition, the incidences of pancreatic fistula and abdominal abscess were significantly higher and the rate of introduction of adjuvant chemotherapy significantly lower in the high-CAR group. CONCLUSION: The CAR was a risk factor influencing survival in patients who underwent curative treatment for gastric cancer. An effective perioperative care plan and surgical strategy need to be developed according to the CAR.
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Authors | Toru Aoyama, Masato Nakazono, Kenki Segami, Shinsuke Nagasawa, Kazuki Kano, Takanobu Yamada, Yukio Maezawa, Kentaro Hara, Itaru Hashimoto, Hideaki Suematsu, Hayato Watanabe, Kosuke Takahashi, Masakatsu Numata, Hiroshi Tamagawa, Norio Yukawa, Yasushi Rino, Takashi Ogata, Takashi Oshima |
Journal | In vivo (Athens, Greece)
(In Vivo)
2021 Nov-Dec
Vol. 35
Issue 6
Pg. 3475-3482
ISSN: 1791-7549 [Electronic] Greece |
PMID | 34697184
(Publication Type: Journal Article)
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Copyright | Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved. |
Chemical References |
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Topics |
- C-Reactive Protein
(analysis)
- Humans
- Neoplasm Recurrence, Local
- Prognosis
- Retrospective Studies
- Stomach Neoplasms
(surgery)
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