Selective therapeutic cooling: To maximize benefits and minimize side effects related to hypothermia.

Abstract

Selective therapeutic cooling is a promising technique for reducing final infarct volume and improving outcomes in ischemic stroke, especially as research regarding brain reperfusion continues to be explored. A recent study provided promising results on the safety and feasibility of selective therapeutic hypothermia via a closed-loop cooling catheter system for intra-carotid blood cooling in an ovine stroke model, but they failed to find efficacy of this method in this model. It is a major step forward from bench to bed side, but enhancing benefits of selective therapeutic cooling may need to take into account a more targeted induction of brain hypothermia and should mitigate potential side effects related to inducing hypothermia.

• Authors: Di Wu, Jian Chen, Xuxiang Zhang, Roxanne Ilagan, Yuchuan Ding, Xunming Ji
• Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (J Cereb Blood Flow Metab) Vol. 42 Issue 1 Pg. 213-215 (01 2022) ISSN: 1559-7016 [Electronic] United States
• PMID: 34670442 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Topics

• Animals
• Brain Infarction (physiopathology, therapy)
• Disease Models, Animal
• Humans
• Hypothermia, Induced
• Ischemic Stroke (physiopathology, therapy)
• Sheep