Association between uric acid and the prognosis of acute ischemic stroke: A systematic review and meta-analysis.

Abstract

AIMS:

Meta-analysis was performed to assess the value of serum uric acid in the prognosis of ischemic stroke.

DATA SYNTHESIS:

We searched the databases of PubMed, Embase, and Web of Science. The literature we searched was published from the establishment of the database to January 2021. The references of the included literature were also collected. Two researchers sifted through the literature according to the inclusion and exclusion criteria and extracted the data. Stata 16.0 software was used for meta-analysis, and funnel plots were used to evaluate publication bias. Ten studies fulfilled the research criteria and were eventually included, and the analysis results showed that there was no significant association between serum uric acid and the functional outcome (OR = 0.99, 95% CI; 0.97-1.10), poor outcome (OR = 1.07, 95% CI; 0.99-1.15), vascular events (OR = 0.86, 95% CI; 0.52-1.41), and mortality (OR = 1.08, 95% CI; 0.93-1.24) related to ischemic stroke.

CONCLUSIONS:

There was no significant correlation between serum uric acid level and prognosis of ischemic stroke.

• Authors: Meng Zhang, Yuan Wang, Kun Wang, Ruihua Yin, Xudong Pan, Aijun Ma
• Journal: Nutrition, metabolism, and cardiovascular diseases : NMCD (Nutr Metab Cardiovasc Dis) Vol. 31 Issue 11 Pg. 3016-3023 (10 28 2021) ISSN: 1590-3729 [Electronic] Netherlands
• PMID: 34625360 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Systematic Review)
• Copyright: Copyright © 2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

Chemical References

• Biomarkers
• Uric Acid

Topics

• Adult
• Aged
• Biomarkers (blood)
• Female
• Humans
• Ischemic Stroke (blood, diagnosis, mortality, therapy)
• Male
• Middle Aged
• Prognosis
• Risk Assessment
• Risk Factors
• Uric Acid (blood)