Quality of life of survivors 1 year after the diagnosis of diffuse large B-cell lymphoma: a LYSA study.

Abstract

Health-related quality of life (HRQoL) is a multidimensional concept including physical, emotional, social, and cognitive functions, disease symptoms, and side effects of treatment. Differences in HRQoL due to gender, existence of comorbidities, and number of chemotherapy cycles are little explored in diffuse large B-cell lymphoma (DLBCL) survivors. Our objective was to investigate whether differences in HRQoL in function of these factors exist 1 year after the diagnosis of DLBCL. One hundred and one patients, enrolled in the RT3 (Real-Time Tailored Therapy) Study, answered self-administrated European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30), EORTC High-Grade Non-Hodgkin Lymphoma (NHL-HG29), Hospital Anxiety and Depression Scale (HADS), Post Traumatic Growth Inventory (PTGI), and Multidimensional Fatigue Inventory (MFI) questionnaires. Adjusted means of scores were calculated in multivariate linear regression models. Fifty-seven survivors (mean age of 58.5 years) answered all questionnaires. Women have significantly higher scores of posttraumatic growth and lower physical functioning than men (P < 0.04). Survivors with comorbidities have increased physical fatigue and symptom burden, increased emotional impact, mental fatigue and depression, and reduced physical functioning and global health status (all P < 0.05). A greater number of cycles of chemotherapy increase the level of symptoms (pain, neuropathy, and dyspnoea; P < 0.05). The various aspects related to HRQoL should be discussed with DLBCL patients and investigated, with the aim of developing strategies to ensure appropriate psychosocial and supportive care and to improve the HRQoL in these patients.

• Authors: Alexandra-Cristina Paunescu, Christiane Bergman Copie, Sandra Malak, Steven Le Gouill, Vincent Ribrag, Krimo Bouabdallah, David Sibon, Gerhard Rumpold, Marie Preau, Nicolas Mounier, Corinne Haioun, Fabrice Jardin, Caroline Besson
• Journal: Annals of hematology (Ann Hematol) Vol. 101 Issue 2 Pg. 317-332 (Feb 2022) ISSN: 1432-0584 [Electronic] Germany
• PMID: 34617134 (Publication Type: Clinical Trial, Journal Article)
• Copyright: © 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Topics

• Adult
• Aged
• Aged, 80 and over
• Cancer Survivors
• Female
• Health Status
• Humans
• Lymphoma, Large B-Cell, Diffuse (diagnosis, epidemiology)
• Male
• Middle Aged
• Quality of Life
• Surveys and Questionnaires
• Young Adult