Contact Allergy to Two Aluminum Salts in Consecutively Patch-Tested Dermatitis Patients.

Abstract

BACKGROUND:

Recently, aluminum chloride hexahydrate (ACH) 10.0% petrolatum (pet) was recommended for patch testing to detect aluminum contact allergy. Aluminum lactate (AL) may be as reliable a test substance as ACH.

OBJECTIVE:

We aimed to investigate the frequencies of aluminum allergy when ACH and AL were used in patch testing consecutive patients.

METHODS:

Petrolatum preparations of ACH 10.0% and AL 12.0% were added to the baseline series in 2010-2017. Aluminum chloride hexahydrate 10.0% pet was added to the children baseline series from July 1, 2012, to December 31, 2017.

RESULTS:

A total of 5448 patients were patch tested with the extended baseline series and 196 children with the extended children baseline series. Forty-eight of the 5448 adults (0.9%) and 10 of the 196 children (5.1%) were diagnosed with aluminum contact allergy. A significant difference was found between the aluminum allergy frequencies in children and adults patch tested with ACH in 2013-2017 (P < 0.001). The difference between the frequencies of contact allergies for the 2 aluminum salts is not statistically significant.

CONCLUSIONS:

Patch testing with ACH and AL demonstrated similar contact allergy frequencies. To detect aluminum allergy, patch testing with ACH 10.0% pet is recommended. Aluminum chloride hexahydrate 10.0% pet should be considered for inclusion in baseline series for patch testing adults and children.

• Authors: Ingrid Siemund, Jakob Dahlin, Monica Hindsén, Erik Zimerson, Annarita Antelmi, Nils Hamnerius, Inese Hauksson, Marléne Isaksson, Ann Pontén, Martin Mowitz, Cecilia Svedman, Magnus Bruze
• Journal: Dermatitis : contact, atopic, occupational, drug (Dermatitis) 2022 Jan-Feb 01 Vol. 33 Issue 1 Pg. 31-35 ISSN: 2162-5220 [Electronic] United States
• PMID: 34570735 (Publication Type: Journal Article)
• Copyright: Copyright © 2021 American Contact Dermatitis Society. All Rights Reserved.

Chemical References

• Allergens
• Aluminum Compounds
• Aluminum Chloride

Topics

• Adult
• Age Factors
• Allergens (administration & dosage, adverse effects)
• Aluminum Chloride (administration & dosage, adverse effects)
• Aluminum Compounds (adverse effects)
• Child
• Dermatitis, Allergic Contact (diagnosis, etiology)
• Female
• Humans
• Intradermal Tests (methods)
• Male
• Patch Tests (methods)
• Risk Factors