Soluble B7-H3 in Ovarian Cancer and Its Predictive Value.

Abstract

The content of the soluble form of protein of the key point of immunity B7-H3 (sB7-H3) in the blood plasma of 75 patients with epithelial ovarian cancer before treatment was measured by ELISA. It is known that B7-H3 belongs to the immunoglobulin superfamily (B7 molecule family) and is involved in the regulation of the immune response mediated by T cells. The sB7-H3 concentration correlated with the clinical and morphological parameters of ovarian cancer. The content of sB7-H3 was higher at the later stages of the disease, in the presence of ascites, and in patients with poorly differentiated ovarian cancer. It was revealed that increased plasma content of sB7-H3 in patients with epithelial ovarian cancer is associated with unfavorable prognosis of the disease. Therefore, sB7-H3 can be used as a prognostic marker in ovarian cancer patients.

• Authors: O V Kovaleva, T P Belova, E A Korotkova, D N Kushlinskii, A N Gratchev, N A Petrikova, D A Kudlay, N E Kushlinskii
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 171 Issue 4 Pg. 472-474 (Aug 2021) ISSN: 1573-8221 [Electronic] United States
• PMID: 34542756 (Publication Type: Journal Article)
• Copyright: © 2021. Springer Science+Business Media, LLC, part of Springer Nature.

Chemical References

• B7 Antigens
• Biomarkers, Tumor
• CD276 protein, human

Topics

• Adult
• Aged
• Aged, 80 and over
• B7 Antigens (blood)
• Biomarkers, Tumor (blood)
• Carcinoma, Ovarian Epithelial (blood, diagnosis, mortality, pathology)
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Middle Aged
• Ovarian Neoplasms (blood, diagnosis, mortality, pathology)
• Predictive Value of Tests
• Prognosis
• Survival Analysis