Abstract | BACKGROUND: METHODS: The protocol was registered (Prospero: CRD42019136631) and the search was conducted in the MEDLINE, PEDro, Cochrane Library, CINAHL, Embase, and LILACS databases, and in the clinical trials registries, until July 2020. We included randomized clinical trials comparing HFNC versus CPAP use in premature infants born at less than 37 weeks of gestational age. The main outcome measures were the development of BPD, air leak syndrome, and nasal injury. The methodological quality of the included studies was assessed using the Cochrane risk of bias tool and the GRADE system was used to summarize the evidence recommendations. Meta-analyses were performed using software R. RESULTS: No difference was found between HFNC or CPAP for the risk of BPD (RR: 1.10; 95% CI: 0.90-1.34), air leak syndrome (RR: 1.06; 95% CI: 0.52-2.14), and nasal trauma (RR: 2.00; 95% CI: 0.64-6.25), with a very low level of evidence. CONCLUSION(S): The HFNC showed similar results when compared to CPAP in relation to the risk of BPD, air leak syndrome, and nasal injury. In the literature, no randomized clinical trial has been found with BPD as the primary outcome to support possible outcomes.
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Authors | Sabrina de Jesus Brito, Sabrina Pinheiro Tsopanoglou, Endi Lanza Galvão, Franciele Angelo de Deus, Vanessa Pereira de Lima |
Journal | BMC pediatrics
(BMC Pediatr)
Vol. 21
Issue 1
Pg. 407
(09 16 2021)
ISSN: 1471-2431 [Electronic] England |
PMID | 34530788
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Systematic Review)
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Copyright | © 2021. The Author(s). |
Topics |
- Bronchopulmonary Dysplasia
(epidemiology, etiology, prevention & control)
- Cannula
- Continuous Positive Airway Pressure
- Humans
- Infant
- Infant, Newborn
- Infant, Premature
- Infant, Premature, Diseases
- Respiratory Distress Syndrome, Newborn
(prevention & control)
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