Abstract | BACKGROUND: Developing easy-to-access biomarkers is crucial in Major Depressive Disorder. The retina has already been suggested as relevant. However, there is a need for a global and local assessment of whole retinal function using a reproducible, standardized protocol allowing for comparison across studies. Our aim is to assess whole retinal function in patients with actual unipolar Major Depressive Episode ( MDE) using pattern, flash and multifocal electroretinogram (ERG) according to the International Society for Clinical Electrophysiology of Vision standardized protocols. METHODS: We assessed retinal function in 14 males and females with MDE, diagnosed based on the Diagnostic and Statistical Manual of Mental Disorders, and in age- and sex-matched healthy controls. RESULTS: Comparing the patients with the controls, we observed the following using multifocal ERG: a significant increase in N1 peak time in ring 3 and a decrease in P1 amplitude in ring 2; using pattern ERG: a significant increase in P50 peak time; using flash ERG: a decrease in a- and b-wave peak time and an increase in the b-wave amplitude in dark-adapted 3.0, a decrease in a- and b-wave peak time and an increase in both wave amplitudes in light-adapted 3.0, and a decrease in the b-wave peak time in light-adapted flicker. LIMITATIONS: Sample size. Contribution of pharmacological treatments to the outcomes cannot be formally excluded. CONCLUSIONS: Patients with MDE exhibit delayed signaling in the central retina and hyperreactivity to light in the periphery. Central retinal function may be a marker of psychomotor retardation and cognitive impairment in MDE.
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Authors | Eve Cosker, Marie Moulard, Cédric Baumann, Amandine Luc, Karine Angioi-Duprez, Vincent Laprévote, Raymund Schwan, Thomas Schwitzer |
Journal | Journal of affective disorders
(J Affect Disord)
Vol. 295
Pg. 453-462
(12 01 2021)
ISSN: 1573-2517 [Electronic] Netherlands |
PMID | 34507226
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2021 Elsevier B.V. All rights reserved. |
Topics |
- Depressive Disorder, Major
- Electroretinography
- Female
- Humans
- Male
- Photic Stimulation
- Retina
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