Abstract | RATIONALE: OBJECTIVE: METHODS: In this study, Mice lacking apolipoprotein E ( ApoE-/-) were randomly divided into four groups. The mice of the control and MI groups were fed normal diet for 24-weeks, while the mice of AS and AS + MI groups were fed high-fat diet (HFD). After 23 weeks, the mice of MI and AS + MI groups were ligated with coronary arteries. A week later, after echocardiography, analysis of plaque and myocardium were conducted on aortic and heart, then the serum, aorta and heart tissues were further detected. RESULTS: Our results showed that AS model mice exhibited significant body weight gain, dyslipidemia and atherosclerotic lesions formation which were in accordance with the pathological changes of AS. Co-treatment with AS and MI led to higher operative mortality and heart pathological were in accordance with the pathological changes of MI. In addition, Echocardiography and NT pro-BNP revealed co-treatment with AS and MI led to deterioration of cardiac function. AS also aggravated myocardial inflammatory cell infiltration and fibrosis post-MI. CONCLUSIONS:
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Authors | Jianbing Wang, Shijun Shan, Anqi Lyu, Yinsheng Wan, Jun Zhang |
Journal | Biochemical and biophysical research communications
(Biochem Biophys Res Commun)
Vol. 576
Pg. 100-107
(10 22 2021)
ISSN: 1090-2104 [Electronic] United States |
PMID | 34482022
(Publication Type: Journal Article)
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Copyright | Copyright © 2021. Published by Elsevier Inc. |
Topics |
- Animals
- Atherosclerosis
(metabolism, pathology)
- Diet, High-Fat
- Disease Models, Animal
- Disease Progression
- Dyslipidemias
(physiopathology)
- Female
- Mice
- Mice, Inbred C57BL
- Mice, Knockout, ApoE
(genetics, metabolism)
- Myocardial Infarction
(metabolism, pathology)
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