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Unexpected low prevalence of delta antibodies in the east Amazon region and São Paulo: evidence for regional differences in the epidemiology of delta hepatitis virus within Brazil.

Abstract
Antibodies (anti-HD) to hepatitis delta virus (HDV) were tested by radioimmunoassay in 207 human serum samples from the eastern Amazon (states of Pará and Amapá) and São Paulo, Brazil. 42 Amazon HBsAg asymptomatic carriers were negative for anti-HD. 84 São Paulo HBsAg asymptomatic carriers were also negative. Among the 81 HBsAg patients from São Paulo with different liver diseases, only one had anti-HD. Liver biopsy of this chronic active hepatitis case was positive for HBsAg, HBcAg and HDAg in liver, by an immunoperoxidase technique. The low prevalence of HDV infections in São Paulo and eastern Amazon was unexpected and contrasts with the recent reports of high prevalence in the western Amazon region. Such regional differences emphasize the need for extensive and precise worldwide epidemiological studies of HDV.
AuthorsE Strauss, L C Gayotto, L C da Silva, V A Alves, F Carrilho, D A Chamone, E F da Silva, G Porta, C Granato, C Trepo
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene (Trans R Soc Trop Med Hyg) Vol. 81 Issue 1 Pg. 73-4 ( 1987) ISSN: 0035-9203 [Print] England
PMID3445327 (Publication Type: Journal Article)
Chemical References
  • Antigens, Viral
  • Hepatitis Antibodies
  • Hepatitis B Core Antigens
  • Hepatitis B Surface Antigens
  • Hepatitis delta Antigens
  • hepatitis delta virus large antigen
Topics
  • Adult
  • Antigens, Viral (analysis)
  • Brazil
  • Hepatitis Antibodies (analysis)
  • Hepatitis B Core Antigens (analysis)
  • Hepatitis B Surface Antigens (analysis)
  • Hepatitis D (immunology)
  • Hepatitis Delta Virus (immunology)
  • Hepatitis delta Antigens
  • Humans
  • Liver (immunology)
  • Male

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