Pseudosterins A-C, Three 1-Ethyl-3-formyl-β-carbolines from Pseudostellaria heterophylla and Their Cardioprotective Effects.

Abstract

Pseudostellaria heterophylla is used in China not only as a functional food but also as an herb to tonify the spleen, enhance immunity, and treat palpitation. Our previous investigation showed that a fraction enriched in glycosides obtained from the roots of P. heterophylla possessed pronounced protective effects on H9c2 cells against CoCl2-induced hypoxic injury. However, the active compounds responsible for the observed effects were still unknown. In the current investigation, pseudosterins A-C (1-3), three new alkaloids with a 1-ethyl-3-formyl-β-carboline skeleton, together with polydatin, have been isolated from the active fraction. Their structures were elucidated on the basis of spectroscopic analysis and quantum chemical calculations. The four compounds showed cardioprotective effects against sodium hydrosulfite-induced hypoxia-reoxygenation injury in H9c2 cells, with the three alkaloids being more potent. This is also the first report of alkaloids with a β-carboline skeleton isolated from P. heterophylla as cardioprotective agents.

• Authors: Guo-Bo Xu, Qin-Feng Zhu, Zhen Wang, Chun-Li Zhang, Xin Yang, Jin-Juan Zhang, Fu-Rui Wang, Jun Liu, Meng Zhou, Yong-Lin Wang, Xun He, Li-She Gan, Shang-Gao Liao
• Journal: Molecules (Basel, Switzerland) (Molecules) Vol. 26 Issue 16 (Aug 20 2021) ISSN: 1420-3049 [Electronic] Switzerland
• PMID: 34443633 (Publication Type: Journal Article)

Chemical References

• Alkaloids
• Carbolines
• Cardiotonic Agents
• Glycosides
• Plant Extracts

Topics

• Alkaloids (chemistry, pharmacology)
• Animals
• Carbolines (chemistry, pharmacology)
• Cardiotonic Agents (chemistry, pharmacology)
• Caryophyllaceae (chemistry)
• Cell Line
• China
• Glycosides (chemistry, pharmacology)
• Hypoxia (drug therapy)
• Plant Extracts (chemistry, pharmacology)
• Plant Roots (chemistry)
• Rats