Inflammatory bowel disease (IBD) is a group of immune-mediated conditions. Immune activity is varied by age and gender. The present study is aimed at investigating the effect of age and gender on the positive rates of anti-Saccharomyces cerevisiae
antibodies (ASCA),
anti-neutrophil cytoplasmic antibodies (
ANCA), anti-intestinal goblet cell
antibodies (GAB), and
antibodies to exocrine pancreas (PAB) in IBD patients. A total of 1871 hospitalized patients with confirmed IBD were included in this study. Sera were obtained from each subject for antibody measurement by indirect immunofluorescence assay. The positive rates of
ANCA IgG and
IgA were higher in female patients than those in male patients (P < 0.001) while the positive rate of PAB
IgG was just reversed (P < 0.001). Moreover, the median ages of patients with positive
ANCA IgG and
IgA were higher than patients with negative
antibodies (P = 0.0019 and P = 0.0110, respectively), while the median ages of patients with positive PAB
IgG and
IgA were significantly lower than patients with negative PAB (P < 0.0001). The serum levels of
ANCA IgG and
IgA were potentiated in old female patients, while serum PAB
IgG was easy to be detected in the young male patients with IBD.