Abstract | BACKGROUND: OBJECTIVES: To assess the clinical efficacy of benzylpenicillin plus ceftriaxone for the management of enterococcal endovascular infections, in addition to assessing this combination's in vitro synergy. PATIENTS AND METHODS: RESULTS: Patients had endovascular infections of native cardiac valves (n = 11), mechanical or bioprosthetic cardiac valves (n = 7), pacemaker leads (n = 1) or left ventricular assistant devices (n = 1). The median duration of OPAT was 22 days, and the most frequent antimicrobial regimen was benzylpenicillin 14 g/day via continuous infusion and ceftriaxone 4 g once daily via short infusion. Rates of unplanned readmissions were high (30%), although rates of relapsed bacteraemia (5%) and 1 year mortality (15%) were comparable to the published literature. Benzylpenicillin less frequently displayed a synergistic interaction with ceftriaxone when compared with amoxicillin (3 versus 4 out of 6 isolates). CONCLUSIONS:
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Authors | Paul R Ingram, Jacinta Ng, Claire Mathieson, Shakeel Mowlaboccus, Geoffrey Coombs, Edward Raby, John Dyer |
Journal | JAC-antimicrobial resistance
(JAC Antimicrob Resist)
Vol. 3
Issue 3
Pg. dlab128
(Sep 2021)
ISSN: 2632-1823 [Electronic] England |
PMID | 34377984
(Publication Type: Journal Article)
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Copyright | © The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. |