Cannabinoids for skin diseases and hair regrowth.

Abstract

The use of cannabis for skin diseases and hair regrowth is at the preliminary stage.

LEGALIZATION:

Many countries have approved cannabis for medical use; however, four countries Canada, Uruguay, South Africa, and Georgia have legalized it for both medical and recreational purposes.

THE ENDOCANNABINOID SYSTEM:

The endocannabinoid system may maintain skin homeostasis; two notable endocannabinoids include 2-Arachidonoylglycerol (2-AG) and N-arachidonoylethanolamine (AEA).

ROUTES OF ADMINISTRATION AND PHARMACOKINETICS:

Topical cannabinoids can avoid the first-pass metabolism and reduce respiratory side effects; however, the high hydrophobicity of cannabinoids may hinder percutaneous absorption.

SKIN DISORDERS AND HAIR GROWTH:

Human clinical studies suggest that cannabinoids may be used in eczema, acne, pruritus, and systemic sclerosis treatment. Cannabidiol (CBD) may enhance hair growth via multiple mechanisms.

SAFETY:

Topical cannabis may cause mild side effects such as pruritus, burning, erythema, and stinging; they are relatively safer than inhalation and oral cannabis. Cannabis use may be associated with allergic symptoms and reduced immune response to live vaccination.

CANNABINOIDS IN PRACTICE:

Despite growing interest, dermatologists should be cautious prescribing cannabinoids due to insufficient clinical data on both efficacy and safety.

• Authors: Aditya K Gupta, Mesbah Talukder
• Journal: Journal of cosmetic dermatology (J Cosmet Dermatol) Vol. 20 Issue 9 Pg. 2703-2711 (Sep 2021) ISSN: 1473-2165 [Electronic] England
• PMID: 34363728 (Publication Type: Journal Article, Review)
• Copyright: © 2021 Wiley Periodicals LLC.

Chemical References

• Cannabinoids
• Cannabidiol

Topics

• Cannabidiol
• Cannabinoids (adverse effects)
• Cannabis
• Hair
• Humans
• Skin Diseases (chemically induced, drug therapy)