[Therapy-Related Acute Myeloid Leukemia with 11q23 Abnormality That Developed after Chemotherapy for Colorectal Cancer].

Abstract

The patient developed Stage Ⅳ transverse colon cancer at the age of 72 years and was treated with an 8-course XELOX regimen(capecitabine and oxaliplatin)every 3 weeks after resection. Six years and 9 months after the end of treatment, at the age of 79 years, WBC levels were found to have markedly increased to 10×104/µL in the patient, and acute leukemia was suspected; subsequently, the patient was hospitalized. Bone marrow was aspirated and analyzed, and the results showed that 95% of leukemic cells were positive for esterase staining. Chromosomal examination revealed t(6 ; 11)(q27 ; q23), ie, the diagnosis of therapy-related acute myeloid leukemia(t-AML)with 11q23 abnormality. CR was achieved by chemotherapy, but the disease soon recurred; the patient died 7 months after the onset of t-AML, with the cause being t- AML with 11q23 abnormality that developed 6 years and 9 months after treatment for colorectal cancer with oxaliplatin and capecitabine without undergoing MDS. Since there is a possibility of leukemia induction following oxaliplatin treatment, more such cases need to be monitored in the future.

• Authors: Makoto Saito, Toru Miyajima, Reiki Ogasawara, Emi Yokoyama, Koh Izumiyama, Akio Mori, Masanobu Morioka, Takeshi Kondo
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 48 Issue 7 Pg. 971-974 (Jul 2021) ISSN: 0385-0684 [Print] Japan
• PMID: 34267039 (Publication Type: Journal Article)

Chemical References

• Myeloid-Lymphoid Leukemia Protein
• Histone-Lysine N-Methyltransferase

Topics

• Aged
• Chromosome Aberrations
• Colorectal Neoplasms (drug therapy)
• Histone-Lysine N-Methyltransferase
• Humans
• Leukemia, Myeloid, Acute (chemically induced, drug therapy)
• Myeloid-Lymphoid Leukemia Protein (genetics)