Appropriate body mass index cutoffs for type 2 diabetes in Xinjiang population: defining the influence of liver aminotransferase.

Abstract

BACKGROUND/PURPOSE:

Recent study suggested that type 2 diabetes (T2DM) attributed to body mass index (BMI) could be influenced by liver aminotransferase. We aim to ascertain the cut-off point of BMI associated with T2DM and the influence of both elevated aminotransferase (AST) and alanine aminotransferase (ALT).

MATERIALS AND METHODS:

In our retrospective cohort study, T2DM was diagnosed when FBS ≥ 7.0 mmol/L, BMI of participants with baseline fasting (FBS) < 7.0 mmol/L was divided by percentiles and by aminotransferanse (ALT and AST ≥ 20 U/L, ALT or AST < 20 U/L). Hazard ratios and the turning point of BMI of high T2DM risk was estimated in totality and different aminotransferanse groups.

RESULTS:

During an average follow-up time of 3.71 years of 33346 participants, 1486 developed T2DM, and the average baseline BMI of participants who developed T2DM was 26.22 kg/m2. Cumulative incidence of T2DM was more than 5% when ALT and AST ≥ 20U/L, age over 44, male sex or BMI over 25.39 kg/m2; The risk of T2DM incidence increased as the BMI grow. The turning point of BMI at high risk of T2DM was 25.0 kg/m2 in totality, 25.1 kg/m2 when ALT or AST < 20 U/L and 26.1 kg/m2 when ALT and AST ≥ 20U/L.

CONCLUSIONS:

BMI of 25.0 kg/m2 was the cutoff point for T2DM development, and there is greater association between BMI and T2DM when ALT or AST < 20 U/L.

• Authors: Jing-Yuan Xu, Long-Bao Yang, Zhi-Yi Han, Kai Wang, Zhen-Hua Yin, Ting Wu, Yong Shao, Xiao-Lan Lu
• Journal: Oncotarget (Oncotarget) Vol. 12 Issue 14 Pg. 1398-1405 (Jul 06 2021) ISSN: 1949-2553 [Electronic] United States
• PMID: 34262650 (Publication Type: Journal Article)
• Copyright: Copyright: © 2021 Xu et al.