Abstract | INTRODUCTION: METHODS: RESULTS: All WDTCs tested positive for TTF-1, PAX8, and E-cadherin. The positive rates of TTF-1, PAX8, and E-cadherin were 93.3, 93.3, and 100%, respectively, in PDTCs and 17.2, 51.7, and 10.3%, respectively, in ATCs. WDTC expressed the lateral cell membrane staining for β- catenin and E-cadherin, whereas PDTC showed circumferential cell membranous expression (fishnet pattern). β- catenin cell membrane expression in ATCs is lost or discontinuous. Carcinoma cells with β- catenin nuclear expression without cell membranous expression were scattered in 72.4% of ATCs but were not observed in the other carcinomas. CONCLUSION: We propose 3 immunohistochemical findings to determine undifferentiated carcinoma cells in the diagnosis of ATC: (1) β- catenin nuclear expression with no or reduced cell membranous expression, (2) the loss or discontinuous pattern of E-cadherin expression, and (3) the loss of PAX8 nuclear expression.
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Authors | Risa Kanematsu, Mitsuyoshi Hirokawa, Aki Tanaka, Ayana Suzuki, Miyoko Higuchi, Seiji Kuma, Toshitetsu Hayashi, Akira Miyauchi |
Journal | Pathobiology : journal of immunopathology, molecular and cellular biology
(Pathobiology)
Vol. 88
Issue 5
Pg. 351-358
( 2021)
ISSN: 1423-0291 [Electronic] Switzerland |
PMID | 34237735
(Publication Type: Journal Article)
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Copyright | © 2021 S. Karger AG, Basel. |
Chemical References |
- Biomarkers, Tumor
- CTNNB1 protein, human
- Cadherins
- beta Catenin
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Topics |
- Biomarkers, Tumor
- Cadherins
(genetics, immunology)
- Carcinoma, Squamous Cell
(genetics, immunology, metabolism)
- Humans
- Immunohistochemistry
(methods, standards)
- Paraffin Embedding
- Thyroid Carcinoma, Anaplastic
(genetics, immunology)
- Thyroid Gland
(pathology)
- beta Catenin
(genetics, immunology)
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