Real-world treatment patterns and effectiveness outcomes in patients with early-stage triple-negative breast cancer.

Abstract

Background: This retrospective, observational study examined real-world treatment patterns and effectiveness outcomes in 450 patients with stage II-IIIB early-stage triple-negative breast cancer treated in the community oncology setting. Methods: Kaplan-Meier methods were used to evaluate event-free survival (EFS), time to recurrence and overall survival (OS). Cox regression models were used to evaluate predictors of EFS and OS by pathological complete response (pCR) status. Results: Among patients receiving neoadjuvant systemic therapy only, pCR was a predictor of EFS and OS. Conclusion: These results highlight the unmet need for therapies that improve outcomes for patients with early-stage triple-negative breast cancer including increasing rates of pCR among patients receiving neoadjuvant therapy.

• Authors: Amin Haiderali, Whitney C Rhodes, Santosh Gautam, Min Huang, Jan Sieluk, Karen E Skinner, Lee S Schwartzberg
• Journal: Future oncology (London, England) (Future Oncol) Vol. 17 Issue 29 Pg. 3819-3831 (Oct 2021) ISSN: 1744-8301 [Electronic] England
• PMID: 34227400 (Publication Type: Journal Article, Observational Study)

Topics

• Adult
• Aged
• Aged, 80 and over
• Female
• Humans
• Middle Aged
• Neoadjuvant Therapy
• Neoplasm Staging
• Progression-Free Survival
• Retrospective Studies
• Treatment Outcome
• Triple Negative Breast Neoplasms (pathology, therapy)