Abstract | BACKGROUND: METHODS: A systematic review of clinical studies reporting subjective or objective ratings of general functioning as primary or secondary outcomes was performed. RESULTS: Four randomized-controlled trials, one open-label clinical study and one case series reported on the efficacy of ketamine/ esketamine on subjective measures of general functioning. Overall, mixed results were reported with respect to the effect across disparate functional measures (e.g., Sheehan Disability Scale [SDS]) using ketamine/ esketamine. A single study demonstrated a significant decrease (i.e., improvement) in SDS total scores in TRD with esketamine treatment; most studies, however, did not report on functional outcomes and have functional outcomes as a (co)-primary outcome measure. LIMITATIONS: Clinical studies that were included evaluated work- or social-related disability as a secondary outcome using subjective rating scales. CONCLUSION: Functional outcomes in adults with TRD receiving ketamine/ esketamine was insufficiently characterized. Available evidence indicates that improvements in general psychosocial functioning is apparent. The association, if any, between symptomatic improvement and functional improvement in TRD, as well as the temporality to improve functioning, are future research vistas.
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Authors | Jason Ng, Joshua D Rosenblat, Leanna M W Lui, Kayla M Teopiz, Yena Lee, Orly Lipsitz, Rodrigo B Mansur, Nelson B Rodrigues, Flora Nasri, Hartej Gill, Danielle S Cha, Mehala Subramaniapillai, Roger C Ho, Bing Cao, Roger S McIntyre |
Journal | Journal of affective disorders
(J Affect Disord)
Vol. 293
Pg. 285-294
(10 01 2021)
ISSN: 1573-2517 [Electronic] Netherlands |
PMID | 34225208
(Publication Type: Journal Article, Review, Systematic Review)
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Copyright | Copyright © 2021. Published by Elsevier B.V. |
Chemical References |
- Antidepressive Agents
- Esketamine
- Ketamine
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Topics |
- Adult
- Antidepressive Agents
(therapeutic use)
- Depression
- Depressive Disorder, Treatment-Resistant
(drug therapy)
- Humans
- Ketamine
(therapeutic use)
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