Resveratrol butyrate esters (RBE) are derivatives of
resveratrol (RSV) and
butyric acid and exhibit
biological activity similar to that of RSV but with higher bioavailability. The aim of this study was designed as an animal experiment to explore the effects of RBE on the serum biochemistry, and fat deposits in the offspring rats exposed to
bisphenol A (BPA), along with the growth and decline of gut microbiota. We constructed an animal model of perinatal
Bisphenol A (BPA) exposure to observe the effects of RBE supplementation on
obesity, blood
lipids, and intestinal microbiota in female offspring rats. Perinatal exposure to BPA led to
weight gain,
lipid accumulation, high levels of blood
lipids, and deterioration of intestinal microbiota in female offspring rats. RBE supplementation reduced the
weight gain and
lipid accumulation caused by BPA, optimised the levels of blood
lipids, significantly reduced the Firmicutes/Bacteroidetes (F/B) ratio, and increased and decreased the abundance of S24-7 and Lactobacillus, respectively. The analysis of faecal
short-chain fatty acid (SCFA) levels revealed that BPA exposure increased the faecal concentration of
acetate, which could be reduced via RBE supplementation. However, the faecal concentrations of
propionate and
butyrate were not only significantly lower than that of
acetate, but also did not significantly change in response to BPA exposure or RBE supplementation. Hence, RBE can suppress BPA-induced
obesity in female offspring rats, and it demonstrates excellent modulatory activity on intestinal microbiota, with potential applications in perinatological research.