Impact of Poly (Styrene-Acrylic Acid) Latex Nanoparticles on Colorectal and Cervical Cancer Cells.

Abstract

Polymer nanoparticles are a promising approach for cancer treatment and detection, due to their biocompatibility, biodegradability, targeting capabilities, capacity for drug loading and long blood circulation time. This study aims to evaluate the impact of poly (styrene-acrylic acid) latex particles on colorectal and cervical cancer cells for anti-tumor efficiency. Latex particles were synthesized by a surfactant-free radical emulsion polymerization process and the obtained polymer particles were characterized in terms of size, size distribution, morphology using scanning electron microscopy (SEM) and transmission electron microscopy (TEM), and electrokinetic property (i.e., zeta potential). Human colorectal and cervical cancer, and normal cell lines, were then treated with different concentrations of poly (styrene-acrylic acid) latex particles. The cell morphology changes were pointed out using an optical microscope and the nanoparticles' (NPs) cell cytotoxicity was evaluated using MTT assay. The obtained results showed that poly (styrene-acrylic acid) latex particles are effective against colorectal and cervical cancer cells if treated with an appropriate particle concentration for 48 h. In addition, it showed that normal cells are the least affected by this treatment. This indicates that these NPs are safe as a drug delivery carrier when used at a low concentration.

• Authors: Munther Alomari, Arwa Almahasheer, Balasamy Rabindran Jermy, Amal A Al-Dossary, Hiba Bahmdan, Vijaya Ravinayagam, Deena Ababneh, Mohamad Tarhini, Abdelhamid Elaissari
• Journal: Polymers (Polymers (Basel)) Vol. 13 Issue 13 (Jun 22 2021) ISSN: 2073-4360 [Electronic] Switzerland
• PMID: 34206194 (Publication Type: Journal Article)