Associations between CT pulmonary opacity score on admission and clinical characteristics and outcomes in patients with COVID-19.

Abstract

This study investigated associations between chest computed tomography (CT) pulmonary opacity score on admission and clinical features and outcomes in COVID-19 patients. The retrospective multi-center cohort study included 496 COVID-19 patients in Jiangsu province, China diagnosed as of March 15, 2020. Patients were divided into four groups based on the quartile of pulmonary opacity score: ≤ 5%, 6-20%, 21-40% and 41% +. CT pulmonary opacity score was independently associated with age, single onset, fever, cough, peripheral capillary oxygen saturation, lymphocyte count, platelet count, albumin level, C-reactive protein (CRP) level and fibrinogen level on admission. Patients with score ≥ 41% had a dramatic increased risk of severe or critical illness [odds ratio (OR), 15.58, 95% confidence interval (CI) 3.82-63.53), intensive care unit (ICU)] admission (OR, 6.26, 95% CI 2.15-18.23), respiratory failure (OR, 19.49, 95% CI 4.55-83.40), and a prolonged hospital stay (coefficient, 2.59, 95% CI 0.46-4.72) compared to those with score ≤ 5%. CT pulmonary opacity score on admission, especially when ≥ 41%, was closely related to some clinical characteristics and was an independent predictor of disease severity, ICU admission, respiratory failure and long hospital stay in patients with COVID-19.

• Authors: Huanyuan Luo, Yuancheng Wang, Songqiao Liu, Ruoling Chen, Tao Chen, Yi Yang, Duolao Wang, Shenghong Ju
• Journal: Internal and emergency medicine (Intern Emerg Med) Vol. 17 Issue 1 Pg. 153-163 (01 2022) ISSN: 1970-9366 [Electronic] Italy
• PMID: 34191219 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2021. Società Italiana di Medicina Interna (SIMI).

Topics

• COVID-19
• Cohort Studies
• Humans
• Retrospective Studies
• SARS-CoV-2
• Tomography, X-Ray Computed