Biodegradable and Peroxidase-Mimetic Boron Oxynitride Nanozyme for Breast Cancer Therapy.

Abstract

Nanomaterials having enzyme-like activities are recognized as potentially important self-therapeutic nanomedicines. Herein, a peroxidase-like artificial enzyme is developed based on novel biodegradable boron oxynitride (BON) nanostructures for highly efficient and multi-mode breast cancer therapies. The BON nanozyme catalytically generates cytotoxic hydroxyl radicals, which induce apoptosis of 4T1 cancer cells and significantly reduce the cell viability by 82% in 48 h. In vivo experiment reveals a high potency of the BON nanozyme for breast tumor growth inhibitions by 97% after 14-day treatment compared with the control, which are 10 times or 1.3 times more effective than the inert or B-releasing boron nitride (BN) nanospheres, respectively. This work highlights the BON nanozyme and its functional integrations within the BN nanomedicine platform for high-potency breast cancer therapies.

• Authors: Lula Zeng, Yuxin Han, Zhiwei Chen, Kang Jiang, Dmitri Golberg, Qunhong Weng
• Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany) (Adv Sci (Weinh)) Vol. 8 Issue 16 Pg. e2101184 (08 2021) ISSN: 2198-3844 [Electronic] Germany
• PMID: 34189868 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2021 The Authors. Advanced Science published by Wiley-VCH GmbH.

Chemical References

• Antineoplastic Agents
• Biocompatible Materials
• Boron Compounds
• boron nitride
• Peroxidase

Topics

• Animals
• Antineoplastic Agents (therapeutic use)
• Biocompatible Materials (therapeutic use)
• Boron Compounds (therapeutic use)
• Breast Neoplasms (drug therapy)
• Cell Line, Tumor
• Cell Survival
• Disease Models, Animal
• Female
• Mice
• Mice, Inbred BALB C
• Nanomedicine
• Nanostructures (therapeutic use)
• Peroxidase (metabolism)