Abstract | BACKGROUND: METHODS: A retrospective review of the electronic medical record and laboratory information systems from January 1, 2014 to August 31, 2017 was conducted to identify all patients with suspected aTTP undergoing TPE. Demographics, comorbidities, pertinent laboratory tests, and temporal TPE procedural data were collected. RESULTS: The median (5th-95th percentile) time from request to initiation of TPE was 5.4 (3.2-10.6) hours. TPE was initiated within 8 hours in 94 of the 108 patients (87.0%). The median (5th-95th percentile) time from request to central venous access was 2.5 (0.5-6.9) hours and from request to plasma product issuance from the blood bank was 3.4 (1.6-8.1) hours. aTTP patients in whom TPE was initiated greater than 6 hours from request did not have worse outcomes compared to those with TPE initiation within 6 hours: in-hospital mortality (2/14 [14.3%] vs 2/21 [9.5%], P = 0.66), median length of stay (9.0 [4.7-44.1] vs 8.3 [3.9-27.0] days, P = 0.76), and median number of days to durable platelet count recovery (4.5 [2.0-9.0] vs 4.0 [2.0-18.0] days, P = 0.66). CONCLUSIONS: The 4 to 8-hour target window from TPE request to initiation appears feasible for a centralized apheresis program servicing a large healthcare system.
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Authors | Jansen N Seheult, Michelle N Stram, Joan Sevcik, Alesia Kaplan, Joseph E Kiss |
Journal | Journal of clinical apheresis
(J Clin Apher)
Vol. 36
Issue 5
Pg. 678-686
(Oct 2021)
ISSN: 1098-1101 [Electronic] United States |
PMID | 34170022
(Publication Type: Journal Article)
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Copyright | © 2021 Wiley Periodicals LLC. |
Topics |
- Adult
- Aged
- Benchmarking
- Delivery of Health Care
- Female
- Humans
- Length of Stay
- Male
- Middle Aged
- Plasma Exchange
(methods)
- Purpura, Thrombotic Thrombocytopenic
(therapy)
- Retrospective Studies
- Young Adult
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