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APOL1-associated kidney disease in northern Nigerians with treated HIV infection.

Abstract
Apolipoprotein L1 (APOL1) high-risk genotypes strongly associate with HIV-associated nephropathy, and antiretroviral therapy reduces the incidence of HIV-associated nephropathy and progression to end-stage kidney disease. Wudil et al. report cross-sectional APOL1 associations with proteinuria and estimated glomerular filtration rate in a northern Nigerian sample with HIV infection on antiretroviral therapy. Multiple ethnic groups with different APOL1 risk variant frequencies were included. Overall, APOL1 was associated with proteinuric chronic kidney disease; however, relationships with underlying causes of nephropathy and progression rates require further study.
AuthorsOpeyemi A Olabisi, Barry I Freedman
JournalKidney international (Kidney Int) Vol. 100 Issue 1 Pg. 19-21 (07 2021) ISSN: 1523-1755 [Electronic] United States
PMID34154709 (Publication Type: Journal Article, Comment)
CopyrightCopyright © 2021 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.
Chemical References
  • APOL1 protein, human
  • Apolipoprotein L1
  • Apolipoproteins
  • Lipoproteins, HDL
Topics
  • Adult
  • Apolipoprotein L1 (genetics)
  • Apolipoproteins (genetics)
  • Cross-Sectional Studies
  • Genotype
  • HIV Infections (complications, drug therapy, epidemiology)
  • Humans
  • Kidney
  • Lipoproteins, HDL (genetics)
  • Nigeria
  • Phenotype

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