The Role of Kallikrein10 (KLK10) Polymorphism in Prostate Cancer Susceptibility.

Abstract

PURPOSE:

The present study aims to investigate the potential role of Kallikrein 10 (KLK10) genotype and allele frequencies in predisposition to prostate cancer.

MATERIALS AND METHODS:

KLK10 (rs7259451) gene polymorphisms were determined by real-time polymerase chain reaction analysis in patients with prostate cancer (n=69) and controls (n=76).

RESULTS:

KLK10 gene frequencies were significantly different in the case and control groups (P = .028). GG carriers were significantly higher in the control group (P = .034), whereas TT carriers were higher in the prostate cancer group (P = .033). Furthermore, The patients with GG genotype had the lowest PSA levels while TT carriers had the highest (P = .005).

CONCLUSION:

 According to the results, we suggested that carrying variant T allele and also carrying homozygote TT genotype could be a potential risk, while ancestral homozygote GG genotype and G allele are risk reducing factors for prostate cancer.

• Authors: Seda Güleç Yılmaz, Faruk Yencilek, Asıf Yıldırım, Fatma Tuba Akdeniz, Altay Burak Dalan, Zerrin Barut, Turgay İsbir
• Journal: Urology journal (Urol J) Vol. 19 Issue 1 Pg. 41-44 (May 26 2021) ISSN: 1735-546X [Electronic] Iran
• PMID: 34089177 (Publication Type: Journal Article)

Chemical References

• KLK10 protein, human
• Kallikreins

Topics

• Alleles
• Case-Control Studies
• Gene Frequency
• Genetic Predisposition to Disease
• Genotype
• Humans
• Kallikreins (genetics)
• Male
• Polymorphism, Single Nucleotide
• Prostatic Neoplasms (genetics)