Abstract | BACKGROUND: METHODS: We will conduct a nationwide cohort study comparing the incidence of superinfections in patients with severe COVID-19 admitted to the ICU compared with ICU patients with influenza A/B in Denmark. We will include approximately 1000 patients in each group from the time period of 1 October 2014 to 30 April 2019 and from 10 March 2020 to 1 March 2021 for patients with influenza and COVID-19, respectively. The primary outcome is any superinfection within 90 days of admission to the ICU. We will use logistic regression analysis comparing COVID-19 with influenza A/B after adjustment for relevant predefined confounders. Secondarily, we will use unadjusted and adjusted logistic regression analyses to assess six potential risk factors (sex, age, cancer [including haematological], immunosuppression and use of life support on day 1 in the ICU) for superinfections and compare outcomes in patients with COVID-19 with/without superinfections, and present descriptive data regarding the superinfections. CONCLUSION:
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Authors | Vibe S Mikkelsen, Marie Helleberg, Nicolai Haase, Morten H Møller, Anders Granholm, Merete Storgaard, Andreas B Jonsson, Kristian Schønning, Nanna Reiter, Sigurður Þór Sigurðsson, Marianne Voldstedlund, Steffen Christensen, Anders Perner |
Journal | Acta anaesthesiologica Scandinavica
(Acta Anaesthesiol Scand)
Vol. 65
Issue 9
Pg. 1345-1350
(Oct 2021)
ISSN: 1399-6576 [Electronic] England |
PMID | 34086975
(Publication Type: Journal Article)
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Copyright | © 2021 Acta Anaesthesiologica Scandinavica Foundation. |
Topics |
- COVID-19
- Cohort Studies
- Denmark
(epidemiology)
- Humans
- Influenza, Human
(complications, epidemiology)
- Intensive Care Units
- SARS-CoV-2
- Superinfection
(epidemiology)
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