Lymphocyte micronuclei frequencies in skin, haematological, prostate, colorectal and esophageal cancer cases: A systematic review and meta-analysis.

Abstract

Micronucleus (MN) assay has been widely used as a biomarker of DNA damage, chromosomal instability, cancer risk and accelerated aging in many epidemiological studies. In this narrative review and meta-analysis we assessed the association between lymphocyte micronuclei (MNi) and cancers of the skin, blood, digestive tract, and prostate. The review identified nineteen studies with 717 disease subjects and 782 controls. Significant increases in MRi for MNi were observed in the following groups: subjects with blood cancer (MRi = 3.98; 95 % CI: 1.98-7.99; p = 0.000) and colorectal cancer (excluding IBD) (MRi = 2.69; 95 % CI: 1.82-3.98, p < 0.000). The results of this review suggest that lymphocyte MNi are a biomarker of DNA damage and chromosomal instability in people with haematological or colorectal cancers. However, the MRi for lymphocyte MNi in subjects with cancers of skin, prostate, esophagus was not significantly increased. More case-control and prospective studies are warranted to further verify the observed trends and to better understand the role of lymphocyte MNi as a biomarker of cancer risk in blood, skin, digestive tract and prostate.

• Authors: Varinderpal S Dhillon, Permal Deo, Stefano Bonassi, Michael Fenech
• Journal: Mutation research. Reviews in mutation research (Mutat Res Rev Mutat Res) 2021 Jan-Jun Vol. 787 Pg. 108372 ISSN: 1388-2139 [Electronic] Netherlands
• PMID: 34083057 (Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
• Copyright: Copyright © 2021 Elsevier B.V. All rights reserved.

Topics

• Chromosomal Instability (genetics)
• Colorectal Neoplasms (genetics)
• DNA Damage (genetics, physiology)
• Esophageal Neoplasms (genetics, pathology)
• Humans
• Male
• Micronucleus Tests (methods)