[Studies on tryptophan metabolism in calcium oxalate urolithiasis].

Abstract

In 90 patients with calcium oxalate urolithiasis an oral tryptophan-loading test with 5 g L-tryptophan was performed and the 24-hour urinary excretion of xanthurenic acid and kynurenine was measured. In 10 cases pathological deviations and an excretion pattern of tryptophan metabolites via kynurenine similar as in the hereditary vitamin-B6-dependent xanthurenic aciduria in homozygous or heterozygous from were found. Correlations between the oxalate excretion and the tryptophan metabolism do not exist. A 2-year therapy with 60 mg vitamin B6 was favourable in patients with an excretion of more than 300 mumol XA after a tryptophan load.

• Authors: U Grimm, I Steinhauser, K Wulff, A Knapp, M Zschiesche
• Journal: Zeitschrift fur Urologie und Nephrologie (Z Urol Nephrol) Vol. 81 Issue 5 Pg. 299-303 (May 1988) ISSN: 0044-3611 [Print] Germany
• Vernacular Title: Tryptophanstoffwechselstudien bei Calciumoxalat-Urolithiasis.
• PMID: 3407338 (Publication Type: Journal Article)

Chemical References

• Xanthurenates
• Calcium Oxalate
• xanthurenic acid
• Tryptophan
• Pyridoxine

Topics

• Administration, Oral
• Calcium Oxalate (urine)
• Genetic Carrier Screening
• Humans
• Kidney Calculi (genetics, urine)
• Pyridoxine (administration & dosage)
• Tryptophan
• Vitamin B 6 Deficiency (genetics, urine)
• Xanthurenates (urine)