Breast ductal carcinoma in situ with micro-invasion versus ductal carcinoma in situ: a comparative analysis of clinicopathological and mammographic findings.

Abstract

AIM:

To determine the differences in clinicopathological and mammographic findings between ductal carcinoma in situ (DCIS) and ductal carcinoma in situ with micro-invasion (DCIS-MI) and explore clinicopathological and mammographic factors associated with DCIS-MI.

MATERIALS AND METHODS:

All DCIS patients with or without micro-invasion who underwent preoperative mammography at The Affiliated Hospital of Qingdao University from January 2016 through June 2020 were identified retrospectively. The correlations of clinicopathological findings with DCIS-MI were evaluated using univariate and multivariate binary logistic regression analyses. Imaging findings were compared between the groups by using the Pearson chi-square test.

RESULTS:

A total of 445 DCIS lesions and 151 DCIS-MI lesions were included in the final analysis. Large extent (≥2.7 cm), high nuclear grade, comedo-type, negative progesterone receptor (PR), negative oestrogen receptor (ER), high Ki-67 and axillary lymph node metastasis were more frequently found in DCIS-MI than in DCIS (all p<0.05), and the first four of these were found to be independent predictors of DCIS-MI in the multivariate analysis (all p<0.05). Regarding imaging findings, compared to DCIS, DCIS-MI showed fewer occult lesions and more lesions with calcifications in mass, asymmetry, and architectural distortion (p=0.004). Grouped calcifications were usually associated with DCIS, while regional calcifications were commonly found in DCIS-MI (p<0.05).

CONCLUSION:

Large extent, high nuclear grade, comedo-type and negative PR were found to be independent predictors of DCIS-MI. Lesions with calcifications and regional calcifications were more likely associated with DCIS-MI on mammography.

• Authors: M Zhang, Q Lin, X H Su, C X Cui, T T Bian, C Q Wang, J Zhao, L L Li, J Z Ma, J L Huang
• Journal: Clinical radiology (Clin Radiol) Vol. 76 Issue 10 Pg. 787.e1-787.e7 (Oct 2021) ISSN: 1365-229X [Electronic] England
• PMID: 34052010 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright © 2021 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

Topics

• Adult
• Aged
• Aged, 80 and over
• Breast (diagnostic imaging, pathology)
• Breast Neoplasms (diagnostic imaging, pathology)
• Carcinoma, Intraductal, Noninfiltrating (diagnostic imaging, pathology)
• Cohort Studies
• Female
• Humans
• Mammography (methods)
• Middle Aged
• Neoplasm Invasiveness
• Retrospective Studies