Abstract | BACKGROUND: METHODS: Records of a total of 47 consecutive TOF patients (mean age: 43.1 ± 13.2 years, male sex: n = 34 [72.3%]) who underwent ICD implantation for secondary prevention between 2000 and 2018 were reviewed. RESULTS: Twenty (42.6%) patients underwent invasive therapy (radiofrequency catheter ablation, n = 8; surgical ablation with pulmonary valve replacement, n = 12) before ICD implantation. Twenty-seven patients (57.4%) were managed noninvasively. During follow-up (median 80.5 [interquartile range, 28.5-131.0] months), 2 (10.0%) patients in the invasive group and 10 (37.0%) patients in the noninvasive group received appropriate ICD shocks (P = 0.036). Logistic regression analysis showed that invasive therapy was associated with a decreased risk of ICD shocks by 81.1% (odds ratio, 0.189; 95% confidence interval, 0.036-0.990; P = 0.049). Furthermore, invasive therapy was associated with decreased risk of the composite outcomes of ICD shock, death, cardiac transplantation, and hospital admission (odds ratio, 0.090; 95% confidence interval, 0.025-0.365; P = 0.013) compared with noninvasive therapy. CONCLUSIONS: Invasive substrate modification therapy was associated with a lower likelihood of ICD shocks and improvement of long-term outcomes in TOF patients.
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Authors | Satoshi Kawada, Praloy Chakraborty, Eugene Downar, Andreu-Porta Sanchez, Gnalini Sathananthan, Abhishek Bhaskaran, Priyanka Kugamoorthy, Lisa Albertini, Erwin N Oechslin, Candice Silversides, Rachel M Wald, Susan Lucy Roche, Lorna Swan, Rafael Alonso-Gonzalez, Sara Thorne, Louise Harris, Edward Hickey, Kumaraswamy Nanthakumar, Blandine Mondésert, Paul Khairy, Krishnakumar Nair |
Journal | CJC open
(CJC Open)
Vol. 3
Issue 5
Pg. 619-626
(May 2021)
ISSN: 2589-790X [Electronic] United States |
PMID | 34027366
(Publication Type: Journal Article)
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Copyright | © 2021 The Authors. |