Abstract | OBJECTIVE: METHODS: This retrospective observational study queried the National Cancer Institute's Surveillance, Epidemiology, and End Results Program from 2000 to 2016. Surgically treated women with American Joint Commission on Cancer stages T1-2 cervical cancer who had high risk factors (nodal metastasis and/or parametrial invasion) and received additional therapy were examined. Propensity score inverse probability of treatment weighting was used to assess the survival estimates for systemic chemotherapy versus external beam radiotherapy with chemotherapy. RESULTS: Among 2462 patients with high risk factors, 185 (7.5%) received systemic chemotherapy without external beam radiotherapy, of which the utilization significantly increased over time in multivariable analysis (adjusted odds ratio per 1 year increment 1.06, 95% confidence interval (CI) 1.02 to 1.09). In weighted models, adjuvant chemotherapy and combination therapy (external beam radiotherapy and chemotherapy) had comparable overall survival among patients aged <40 years (hazard ratio (HR) 0.73, 95% CI 0.41 to 1.33), in adenocarcinoma or adenosquamous histologies (HR 0.90, 95% CI 0.62 to 1.32), and in those with nodal metastasis alone without parametrial tumor invasion (HR 1.17, 95% CI 0.84 to 1.62). In contrast, systemic chemotherapy alone was associated with increased all cause mortality compared with combination therapy in patients aged ≥40 years (HR 1.57, 95% CI 1.19 to 2.06), with squamous histology (HR 1.63, 95% CI 1.19 to 2.22), and with parametrial invasion alone (HR 1.87, 95% CI 1.09 to 3.20) or parametrial invasion with nodal metastasis (HR 1.64, 95% CI 1.06 to 2.52). CONCLUSION:
|
Authors | Koji Matsuo, David J Nusbaum, Shinya Matsuzaki, Maximilian Klar, Muneaki Shimada, Munetaka Takekuma, Lynda D Roman |
Journal | International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
(Int J Gynecol Cancer)
Vol. 31
Issue 7
Pg. 991-1000
(07 2021)
ISSN: 1525-1438 [Electronic] England |
PMID | 34016702
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | © IGCS and ESGO 2021. No commercial re-use. See rights and permissions. Published by BMJ. |
Topics |
- Adult
- Aged
- Aged, 80 and over
- Chemotherapy, Adjuvant
(methods)
- Female
- Humans
- Middle Aged
- Neoplasm Staging
- Progression-Free Survival
- Risk Factors
- Treatment Outcome
- United States
- Uterine Cervical Neoplasms
(drug therapy, mortality)
- Young Adult
|